Four letter clusters have been given, out of which three are alike in some manner and one is different. Select the one that is different.

The logic followed here is:

Logic: Number of vowel in the word.

1) DHUPM:

The letters are D, H, U, P, M. ⇒ Only one vowel

2) BETIYA:

The letters are B, E, T, I, Y, A. ⇒Two vowel

3) LRENT:

The letters are L, R, E, N, T.⇒ Only one vowel

4) ZGALS:

The letters are Z, G, A, L, S.⇒ Only one vowel

Based on the vowel analysis, BETIYA stands out as the only letter cluster containing more than one vowel.

Hence, the correct answer is "Option 2".