The following experiment was designed to establish the synergy of Bcl2 with genes like Myc in leading to B-cell lymphomas.
F2 Vinanti Teaching 16.08.23 D4

Identify the figure that correctly represents conditions under which mice succumbed to lymphomas.

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CSIR-UGC (NET) Life Science: Held on (6 June 2023 Shift 2)
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  1. F2 Vinanti Teaching 16.08.23 D5
  2. F2 Vinanti Teaching 16.08.23 D6
  3. F2 Vinanti Teaching 16.08.23 D7
  4. F2 Vinanti Teaching 16.08.23 D8

Answer (Detailed Solution Below)

Option 3 : F2 Vinanti Teaching 16.08.23 D7
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The correct answer is Option 3 

Key PointsDiffuse large B-cell lymphoma (DLBCL) 

  • Diffuse large B-cell lymphoma (DLBCL) is the most frequent lymphoma in adults, and is characterized as clinically and biologically heterogeneous lymphomas with diverse response to therapy and variation in clinical behavior.
  • It's well-established that c-MYC and BCL2 play important roles in normal B-cell differentiation and tumorigenesis.
  • B cell lymphoma with dual expression of c-MYC and BCL2 (double-expressor lymphoma, DEL) accounts for approximately one-third of DLBCL cases. 
  • Co-expression of c-MYC and BCL2 in germinal center (GC) B cells, or pan-B cells could induce B cell lymphomas.
  • The tumor-bearing mice have enlarged lymphoid organs, and B cells massively infiltrate into non-lymphoid organs including lung, liver and kidney.
  • The tumor-bearing mice also manifested significantly shorter lifespan than the controls.
  • In addition, adoptive transfer of Co-expression B cells leads to B cell lymphoma and host mice death.

Explanation:

  • According to figure where there is expression of both MYC and BCl2 the mice survival will be least, compared to only MYC gene expression and most survival will be for only for BCl2 gene expression.
  • Hence figure 3 is most appropriate.

Hence the correct answer is Option 3

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